Pregled bibliografske jedinice broj: 240035
Systemic cytokine response during Listeria monocytogenes infection in pregnant Balb/c mice
Systemic cytokine response during Listeria monocytogenes infection in pregnant Balb/c mice // AJRI - American Journal of Reproductive Immunology (Abstract Issue)
Weimar, Njemačka, 2002. str. 152-152 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 240035 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Systemic cytokine response during Listeria monocytogenes infection in pregnant Balb/c mice
(Systemic cytokine response during Listeria monocytogenes infection in pregnant BALB/C mice)
Autori
Abram, Maja ; Vučković, Darinka ; Dorić, Miljenko ; Wraber, Branka
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
AJRI - American Journal of Reproductive Immunology (Abstract Issue)
/ - , 2002, 152-152
Skup
8th Congress of the AASIR
Mjesto i datum
Weimar, Njemačka, 07.09.2002. - 10.09.2002
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Listeria monocytogenes; cytokine; pregnancy; mice
Sažetak
Pregnancy has an important impact on the maternal immune system, associated with a shift in the Th1/Th2 cytokine balance towards a type-2 response. However, listeria induced Th1 type cytokines are essential in host protection against this facultative intracellular bacterium. We have analyzed and compared the kinetics of maternal serum concentrations of IFN-gamma, IL-10, TNF-alpha, IL-6 and KC by ELISA. Serim IFN-gamma levels in infected pregnant mice were significantly reduced in comparison to infected virgin animals, while IL-10 levels were increased, being significantly higher on days 3 and 6 p.i. as compared to infected virgin mice. Upon L. monocytogenes infection, circulating TNF-alpha concentrations were below the detection limit. However, on day 6 p.i., in pregnant mice elevated levels of TNF-alpha were noticed, correlating to the severity of disease. Increased concentrations of IL-6 have been shown to follow the kinetics of bacterial numbers in the liver of infected animals. Murine chemokine KC production in maternal circulation followed a similar patter as IL-6. In comparison to virgin animals, pregnant mice mount lower levels of protective Th1 cytokines and are unable to liminate the pathogen. Increased serum concentrations of IL-10, along with proinflammatory cytokines, may well contribute to the severity of pregnancy-associated listeriosis. Maternal serum IL-6 level showed the higest correlation with the course of infection and pregnancy outcome.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
