Naslov
Intracellular trafficking of Legionella pneumophila.

Autori
Šantić, Marina ; Jones, Snake ; Asare, Rexford ; Abu-Zant, Alaeddin ; Abu Kwaik, Yousef ; Dorić, Miljenko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Acta Microbiologica et Immunologica Hungarica / Marialigeti, K ; Sipos, R - Budimpešta : Akadémiai Kiadó, 2005, 137-138

Skup
1st Central European Forum for Microbiology

Mjesto i datum
Keszthely, Mađarska, 26.10.2005. - 28.10.2005

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Legionella; intracellular trafficking; IFN-gamma

Sažetak
Legionella pneumophila is an intracellular pathogen that modulates biogenesis of its phagosome to svade endocytic vesicle traffic. The Z-egfoneZ/a-containing phagosome (LCP) does not acquire any Bidocytic markers and is remodeled by the endoplasmic reticulum (ER) during early stages. We show bat intracellular replication of L. pneumophila is inhibited in IFN-g activated bone marrow-derived nice macrophages and IFN-g activated human monocyte-derived macrophages (hMDM), in a dose-lependent manner. This inhibition of intracellular replication is associated with maturation of the LCP into a phagolysosome, as documented by the acquisition of Lamp-2, Cathepsin D, and the ly-osomal tracer Texas Red Ovalbumin, and with the failure of the LCPs to be remodeled by the RER. Ike conclude that IFN-g activated macrophages override the ability of L. pneumophila to evade endo-ytic fusion, and the LCP is processed through "default" endosomal lysosomal degradation pathway.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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