Naslov
Lack of association between the 5HT 2A receptor polymorphisms ( T102C) and unipolar affective disorder in a multicentic European study

Autori
Oswald, P. ; Souery, D. ; Massat, I. ; Del-Favero, J. ; Linotte, S. ; Papadimitrou, G. ; Dikeos, D. ; Kaneva, R. ; Milanova, V. ; Oruč, L. ; Ivezić, S. ; Serretti, A. ; Lilli, R. ; Van Broeckhoven, C. ; Mendlewich, J.

Izvornik
European Neuropsychopharmacology (0924-977X) 13 (2003), 5; 365-368

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
serotonin; 5HT2A; receptor polymorfism; unipolar affective dissorede; conditional logistic regression
(serotonin; 5HT2A; receptor polymorfism; unipolar affective dissorede; conditional logistic regress)

Sažetak
We report here a case-control association study with T102C polymorphism in the serotonin 2A receptor gene (HTR2A) in patients affected by unipolar affective disorder (UPAD) and in controls. A total of 284 subjects were genotyped (142 UPAD and 142 controls). All subjects were interviewed using standard diagnostic interviews and matched. A homogenous population of unipolar patients with suicidal attempt was identified. Conditional logistic regression was applied. No association of the HTR2A polymorphism was found in the overall sample of 142 UPAD-control pairs regarding allele and genotype frequencies (P=0.36 and P=0.52 respectively) and homo-heterozygote distributions (P=0.91). This study confirms, in a multicentric European sample, the earlier observations that the T102C HTR2A polymorphism is not associated with UPAD. Nevertheless, a type 2 statistical error cannot be excluded. Therefore, to exclude the implication of HTR2A in UPAD, this result must be replicated in larger samples and in other populations using the transmission disequilibrium test and different polymorphisms around HTR2A.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA