Naslov
Synthetic approaches to bis-peptides attached on polynorbornane molecular scaffolds with well-defined relative positions and distances

Autori
Shang, Muhong ; Warrener, Ronald N. ; Butler, Douglas, N. ; Margetić, Davor

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Proceedings of ECSOC-9 : The Ninth International Electronic Conference on Synthetic Organic Chemistry / - Basel : MDPI Books, 2005

ISBN
3-906980-16-2

Skup
9th International Electronic Conference on Synthetic Organic Chemistry : ECSOC-9

Mjesto i datum
Internet, 30.10.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
norbornene; peptides; cycloadditions

Sažetak
This paper describes novel synthetic approaches to polynorbornane molecular scaffolds substituted with peptides at various, well-defined positions. A library of norbornene building blocks with attached peptides was prepared. Alkene cyclobutane epoxide (ACE) coupling method was used as a key step reaction for connecting of two norbornene building blocks into bis-peptide scaffolds. Photodimerization of cyclobutene diesters offers alternative route to polynorbornane bis-peptides. Pyrrolo-peptides were used for preparation of peptide substituted 7-aza norbornenes. Unsymmetrical bis-peptide scaffolds were prepared by ACE coupling of peptide-norbornane epoxide with another norbornene-peptide block. Chemical elaboration of bridgehead dimethyl esters of ACE products or epoxide ACE reagents was also used for peptide attachment.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA