Naslov
Neonatal sepsis evaluation: culture-positive infection in neonates with and without risk factors

Autori
Pavičić Bošnjak, Anita ; Šeper, Ivanka ; Razum, Svjetlana ; Juka-Kozul, Gorana

Izvornik
Journal of Perinatal Medicine (0300-5577) 33 (2005), Suppl I;

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, stručni

Ključne riječi
neonatal sepsis; risk factors; culture-positive infection

Sažetak
Among 2046 live newborn infants born at University Hospital Merkur Zagreb, Croatia between January 2004 and December 2004 we identified infants &#8805; 1800 g and &#8805; 33 weeks of gestational age without major congenital anomalies as eligible for this study. Newborn infants with risk factors for sepsis (prematurity, rupture of membranes [ROM] &#8805; 12 hours, mother positive for group B streptococcus [GBS], maternal fever and meconium-stained amniotic fluid) or clinical signs during the first 5 days of life suggesting possible infection were evaluated with white blood cell count, differential, C-reactive protein (CRP), and blood culture (cord blood culture immediately after birth in infants with risk factors and peripheral vein blood culture in infants with clinical signs). A total of 245 (12, 0%) infants were evaluated for sepsis, 96 (39, 2%) met criteria for culture-positive, or clinical bacterial infection: 18 (7, 3%) had positive blood cultures, and 78 (31, 8%) had clinical evidence of bacterial infection. GBS was the most common organism isolated (5 [27, 8%]). Only one infant evaluated because of clinical simpotoms had culture-proven sepsis (E. coli). Presence of risk factor for sepsis was overall significantly higher in infants with culture positive infection compared with infants with clinical sepsis (94, 4% vs. 51%, p<0, 05) ; ROM &#8805; 12 h was the most frequent (60% vs. 17, 9%, p<0, 05), followed by maternal fever (16, 7% vs. 5, 1%) and prematurity (16, 7% vs. 12, 8%). Elevated CRP (>10 mg/L) in infants with proven or clinical sepsis was found in 16 of 57 (28, 1%) at risk infants, and in 15 of 39 (38, 4%) with no risk factors. Presence of risk factor is an important factor for detection of newborn infants with early-onset sepsis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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