Naslov
C-reactive Protein is a Strong Predictor of Mortality in Haemodialysis Patients

Autori
Rački, Sanjin ; Zaputović, Luka ; Vujičić, Božidar ; Dvornik, Štefica ; Mavrić, Žarko

Izvornik
Renal Failure (0886-022X) 28 (2006), 5; 427-433

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
C-reactive protein; Renal dialysis; Kidney failure; chronic: Mortality; Inflammation

Sažetak
Background: To establish the baseline cut-off value of C-reactive protein (CRP) that may be predictive of increased overall and cardiovascular mortality in patients with end-stage renal disease (ESRD). Methods: A cohort of 270 prevalent haemodialysis patients treated at Rijeka University Hospital were eligible for the study. Monthly CRP measurements were performed for three consecutive months. Only the patients with CRP values varying <20% were included (n=256). During the follow up, 24 patients were transplanted and therefore excluded from the analysis. The CRP cut-off point of 6.2 mg/L was established by Receiver Operating Characteristic curve. The patients were divided into four groups according to their CRP values. Group 1 included 80 (34.5%) patients with CRP <3.0 mg/L, group 2 included 23 (9.9%) patients with CRP 3.0-6.1 mg/L, group 3 consisted of 18 (7.7%) patients with CRP 6.2-10.0 mg/L, and group 4 included 111 (47.9%) patients with CRP >10.0 mg/L. The survival was evaluated by Kaplan-Meier curve. Results: During the 2-year follow-up, 59 patients died. The major cause of death was cardiovascular disease (64%). Significantly higher overall and cardiovascular mortality was observed in group 3 when compared with groups 1 and 2 (chi square=11.97 ; P < 0.001), and in group 4 when compared with groups 1 and 2 (chi square=14.40 ; P<0.001). Compared with survivors, non-survivors had a higher median CRP value (19.0 [1.5-99.7] mg/L vs. 2.3 [0.1-49.1] mg/L, respectively ; P<0.001). Conclusion: Serum concentration of CRP above 6.2 mg/L is a strong predictor of overall and cardiovascular mortality in patients with ESRD.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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