Naslov
Very slow autoxidation of low-density lipoprotein spares alpha-tocopherol

Autori
Herak, Janko ; Krilov, Dubravka ; Stojanović, Nataša ; Marincel, Jasna

Izvornik
Chemistry and physics of lipids (0009-3084) 94 (1998); 64-70

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Alpha-tocopherol; EPR; Low-density lipoprotein; Oxidation; Oxygen consumption

Sažetak
Low-density lipoprotein (LDL) in solution, supplemented with EDTA, is spontaneously oxidized at pšhysiological temperature. In closed systems, three distinct phases of oxidation are present. In the lag period no change of any of the usually measured markers of oxidation have been detected. In the second phase, oxygen is consumed and subsequently the level of lipid hydroperoxides is increased. In the third phase, after consumption of oxygen, hydroperoxides decrease in concentration and the apoprotein-associated free radicals are formed. In the entire process alpha-tocopherol is conserved. The participation and preservation of alpha-tocopherol in the process is interpreted in terms of the tocopherol-mediated peroxidation. In the latter two phases alpha-tocopherol oscillates between the oxidized and reduced states.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA