Pregled bibliografske jedinice broj: 234284
TFF2 (trefoil family factor2) inhibits apoptosis in breast and colorectal cancer cell lines
TFF2 (trefoil family factor2) inhibits apoptosis in breast and colorectal cancer cell lines // Peptides, 25 (2004), 5; 855-863 doi:10.1016/j.peptides.2003.11.023 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 234284 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
TFF2 (trefoil family factor2) inhibits apoptosis in breast and colorectal cancer cell lines
Autori
Siu, Lai-San ; Romanska, Hanna ; Abel, D Paul ; Baus-Lončar, Mirela ; Kayademir, Tuncay ; Stamp, W.H. Gordon ; Lalani, El-Nasir Lalani
Izvornik
Peptides (0196-9781) 25
(2004), 5;
855-863
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
TFF2 ; Adenocarcinoma ; Cytoprotection
Sažetak
We have recently demonstrated that human TFF2 inhibits apoptosis in the non-TFF2 expressing breast adenocarcinoma cell line MCF-7. In this study we examined the impact of TFF2 and an anti-TFF2 antibody (hSP3) on the survival of other human adenocarcinoma cell lines ; TFF2-positive (LS174T and SW480) and TFF2-negative (MCF-7 and T47D). Addition of TFF2 protected the (TFF2– ) lines but had no effect on those constitutively expressing TFF2. Blocking with hSP3 significantly increased apoptosis in the (TFF2+) cell lines with minimal effect on the (TFF2– ) cells. Our results show that the cytoprotective effect of TFF2 seen in MCF-7 cells is not cell line-specific and can be abrogated by inhibition of its expression.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
