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Pregled bibliografske jedinice broj: 234282

Transcriptional control of TFF3 (intestinal trefoil factor) via promoter binding sites for the nuclear factor kappaB and C/EBP beta

Baus-Lončar, Mirela; Al-azzeh, Ezzal-din; Romanska, Hanna; Lalani, El-Nasir; Stamp, W.H. Gordon; Blin, Niklaus; Kayademir, Tuncay
Transcriptional control of TFF3 (intestinal trefoil factor) via promoter binding sites for the nuclear factor kappaB and C/EBP beta // Peptides, 25 (2004), 5; 849-854 doi:10.1016/j.peptides.2003.11.019 (međunarodna recenzija, članak, znanstveni)

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Naslov
Transcriptional control of TFF3 (intestinal trefoil factor) via promoter binding sites for the nuclear factor kappaB and C/EBP beta

Autori
Baus-Lončar, Mirela ; Al-azzeh, Ezzal-din ; Romanska, Hanna ; Lalani, El-Nasir ; Stamp, W.H. Gordon ; Blin, Niklaus ; Kayademir, Tuncay

Izvornik
Peptides (0196-9781) 25 (2004), 5; 849-854

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Transcription factor NF-kappaB ; Trefoil factor family TFF ; Expression control ; Signalling pathway

Sažetak
The acute phase response is strictly connected with modulation of gene expression. Transcriptional control of many genes is mediated by binding of diverse transcription factors to cis-acting DNA motifs in the respective promoter sequence.We now describe such regulatory elements for the TFF3 gene coding for a peptide involved in response to gut irritation. TNF-alpha stimulation, which induces NF-kappaB activation, evoked up to 10-fold reduction of TFF3 expression in the colon tumour cell line HT-29. Several consensus binding sites for members of the NF-kappaB transcription factor subunits are located in the 5-flanking region of TFF3. Mutating these sites was aimed at discovering which one is responsible for NF-kappaB binding and thus regulation of TFF3 expression.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Medicinski fakultet, Osijek

Profili:

Avatar Url Mirela Baus Lončar (autor)

Poveznice na cjeloviti tekst rada:

doi doi.org www.sciencedirect.com

Citiraj ovu publikaciju:

Baus-Lončar, Mirela; Al-azzeh, Ezzal-din; Romanska, Hanna; Lalani, El-Nasir; Stamp, W.H. Gordon; Blin, Niklaus; Kayademir, Tuncay
Transcriptional control of TFF3 (intestinal trefoil factor) via promoter binding sites for the nuclear factor kappaB and C/EBP beta // Peptides, 25 (2004), 5; 849-854 doi:10.1016/j.peptides.2003.11.019 (međunarodna recenzija, članak, znanstveni)
Baus-Lončar, M., Al-azzeh, E., Romanska, H., Lalani, E., Stamp, W., Blin, N. & Kayademir, T. (2004) Transcriptional control of TFF3 (intestinal trefoil factor) via promoter binding sites for the nuclear factor kappaB and C/EBP beta. Peptides, 25 (5), 849-854 doi:10.1016/j.peptides.2003.11.019.
@article{article, author = {Baus-Lon\v{c}ar, Mirela and Al-azzeh, Ezzal-din and Romanska, Hanna and Lalani, El-Nasir and Stamp, W.H. Gordon and Blin, Niklaus and Kayademir, Tuncay}, year = {2004}, pages = {849-854}, DOI = {10.1016/j.peptides.2003.11.019}, keywords = {Transcription factor NF-kappaB, Trefoil factor family TFF, Expression control, Signalling pathway}, journal = {Peptides}, doi = {10.1016/j.peptides.2003.11.019}, volume = {25}, number = {5}, issn = {0196-9781}, title = {Transcriptional control of TFF3 (intestinal trefoil factor) via promoter binding sites for the nuclear factor kappaB and C/EBP beta}, keyword = {Transcription factor NF-kappaB, Trefoil factor family TFF, Expression control, Signalling pathway} }
@article{article, author = {Baus-Lon\v{c}ar, Mirela and Al-azzeh, Ezzal-din and Romanska, Hanna and Lalani, El-Nasir and Stamp, W.H. Gordon and Blin, Niklaus and Kayademir, Tuncay}, year = {2004}, pages = {849-854}, DOI = {10.1016/j.peptides.2003.11.019}, keywords = {Transcription factor NF-kappaB, Trefoil factor family TFF, Expression control, Signalling pathway}, journal = {Peptides}, doi = {10.1016/j.peptides.2003.11.019}, volume = {25}, number = {5}, issn = {0196-9781}, title = {Transcriptional control of TFF3 (intestinal trefoil factor) via promoter binding sites for the nuclear factor kappaB and C/EBP beta}, keyword = {Transcription factor NF-kappaB, Trefoil factor family TFF, Expression control, Signalling pathway} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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