Naslov
Influence of amoxycillin and clavulanic acid on beta-lactamase production of Branhamella catarrhalis

Autori
Bedenić, Branka ; Žagar, Živojin

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The abstracts of the 6th International Congress for Infectious Diseases, Prague, Check Republic / - Prag, 1994

Skup
6. International Congress for Infectious Diseases

Mjesto i datum
Prag, Češka Republika, 26.04.1994. - 30.04.1994

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Branhamella catarrhalis; amoxycillin; clavulanic acid; beta-lactamases
(Moraxella catarrhalis; amoxacillin; clavulanic acid; beta-lactamases)

Sažetak
Branhamella catarrhalis, previously regarded as a harmless member of the normal nasopharyngeal flora, has periodically been implicated as the major pathogen in representative cases of a variety of infections such as sinusitis, pneumonia, septicemia and meningitis. In additionm, beta-lactamase production of these microorganisms, first described in 1977, has been reported with increasing frequency, up to 80%. The first choice drug for the therapy of the infections caused by beta-lactamase producing strains of B. catarrhalis is amoxycillin combined with clavulanic acid. The aim of our work was to determine the influence of amoxycillin and clavulanic acid on the biosynthesis of beta-lactamase of B. catarrhalis. Our results pointed out that the combination of amoxycillin and clavulanic acid produced only a slight increase in enzyme activity in 5003 and 462 strain. Clavulanic acid alone caused no increase in enzyme production. Ravasio strain showed no increase in enzyme formation after exposure to antibiotics.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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