Naslov
Improvement of early functional atherosclerotic changes in males with hypercholesterolemia after vitamin E supplementation

Autori
Borovničar, Alenka ; Keber, Irena ; Stavljenić Rukavina, Ana ; Zaletel Kragelj, Lijana

Izvornik
Pflugers Archiv : European journal of physiology (0031-6768) 440 (2000), Suppl. 1; R126-R128

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Vitamin E ; hypercholesterolemia

Sažetak
Vitamin E as an antioxidant vitamin reduces the susceptibility of low-density lipoprotein (LDL) cholesterol to oxidation and may have antiatherosclerotic effects. We tested the hypothesis that six months of 400 mg vitamin E supplementation favourably affects early functional changes in atherosclerotic process in subjects with hypercholesterolemia. The diameter of the brachial artery at rest, after reactive hyperemia (representing endothelium- dependent vasodilatation) and after sublingual glyceryl-trinitrate (representing endothelium- independent vasodilatation), were determined by ultrasonographic method (B mode) before and after the intervention period. After the intervention period the brachial endothelium- dependent vasodilatation increased significantly in the vitamin E group while it did not change in the placebo group. In conclusion, six months of oral vitamin E supplementation results in improvement of the endothelium-dependent vasodilatation in men with hypercholesterolemia.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA