Naslov
Biochemical Markers of Bone Metabolism in Postmenopausal Women – the Effect of Hormone Replacement Therapy and Smoking

Autori
Kušec, Vesna ; Stavljenić Rukavina, Ana ; Čubrilo Turek, Mirjana

Izvornik
Croatian Medical Journal (0353-9504) 39 (1998), 1; 23-27

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
bone ; postmenopausal bone loss ; postmenopausal hormone replacement therpy ; postmenopause ; smoking

Sažetak
Aim. Investigation of biochemical markers of bone metabolism in postmenopausal women with respect to hormone replacement therapy and smoking as a risk factor for osteoporosis. Methods. Cross-sectional study of 107 healthy women receiving hormone replacement therapy (24 smokers) and 50 postmenopausal women (20 smokers) who served as a control group. The following biochemical parameters were analyzed in the serum: total calcium, inorganic phosphate, total alkaline phosphatase, procollagen I C-terminal propeptide (PICP), and cross-linked carboxyterminal collagen I telopeptide (ICTP). The effect of hormone replacement therapy and smoking on biochemical parameters was assessed by a two-way ANOVA. Results. Significantly lower values of total calcium, inorganic phosphate, alkaline phosphatase, and ICTP in women on hormone replacement therapy compared to the control group indicated a higher rate of bone remodeling in the untreated postmenopause. In women smokers versus non-smokers, significantly lower values of only ICTP were found. Both hormone replacement therapy and smoking affected total calcium and phosphate levels, with the lowest values in non-smoking women on hormone replacement therapy and the highest in non-smoking control women. Conclusion. Reduction of bone turnover by hormone replacement therapy in menopause was indicated by lower values of biochemical parameters and collagen-related bone markers. Hormone replacement therapy is the prevalent factor affecting biochemical parameters, and probably conceals the possible effect of smoking.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA