Pregled bibliografske jedinice broj: 232658
Action mechanism of photochemotherapy (PUVA) in patients with psoriasis
Action mechanism of photochemotherapy (PUVA) in patients with psoriasis // British Journal od Dermatology Reprint from 154 / Barker, Jonathan ; Griffiths, Christopher (ur.).
London : Delhi: British Association of Dermatologists, 2005. str. 19-20 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 232658 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Action mechanism of photochemotherapy (PUVA) in patients with psoriasis
Autori
Čeović, Romana ; Jakić-Razumović, Jasminka ; Lipozenčić, Jasna
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
British Journal od Dermatology Reprint from 154
/ Barker, Jonathan ; Griffiths, Christopher - London : Delhi : British Association of Dermatologists, 2005, 19-20
Skup
Psoriasis from Gene to Clinic
Mjesto i datum
London, Ujedinjeno Kraljevstvo, 01.12.2005. - 03.12.2005
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
photochemotherapy (PUVA); psoriasis PASI Score
Sažetak
According to current concepts, psoriasis is an autoimmune, T-lymphocyte-induced, cytokine- and chemokine-mediated disease. The exact cause of psoriasis remains unknown, therefore the treatment is symptomatic. Psoralen ultraviolet A (PUVA) photochemotherapy has for years been very successfully used in the treatment of psoriasis vulgaris involving more than 30% of the skin area but the mechanism of its action has not yet been fully elucidated. The aim of the study was to investigate the antiproliferative, antiangiogenic and apoptotic action of photochemotherapy (PUVA), and to compare it with the clinical picture of the disease. Proliferating keratinocyte count was immunohistochemically determined by use of anti Ki-67 antibodies, the number of blood vessels in the dermis by use of F-8 antibodies, and cell count expressing apoptotic oncogenes by use of anti bcl-2 antibodies, all these before and after photochemotherapy (PUVA). Psoriasis Area and Severity Index (PASI) score was determined before and after treatment. The study included 10 patients with psoriasis vulgaris with indications for photochemotherapy (PUVA). Study results demonstrated the antiproliferative, antiangiogenic and apoptotic action of photochemotherapy. Photochemotherapy (PUVA) was found to act efficiently on the main pathogenetic mechanisms of psoriasis, and to significantly improve the clinical picture of patients with psoriasis.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
