Pregled bibliografske jedinice broj: 23203
Amino acid residues conferring specificity of cholinesterases
Amino acid residues conferring specificity of cholinesterases // Periodicum biologorum, 101 (1999), 1; 7-15 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 23203 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Amino acid residues conferring specificity of cholinesterases
Autori
Kovarik, Zrinka
Izvornik
Periodicum biologorum (0031-5362) 101
(1999), 1;
7-15
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
acetylcholinesterase; butyrylcholinesterase; human butyrylcholinesterase active site domains; AChE-inhibitor complexes
Sažetak
The christal structure, sequence comparisons and site-directed mutagenesis of cholinesterases now make it possible to define distinct residues and discrete domains of acetylcholinesterase (EC 3.1.1.7) and butyrylcholinesterase (EC 3.1.1.8) which contribute to overall specificity for reversible ligands, carbamoylating agents and organophosphates. This review focuses on residues of enzymes directly implicated in catalysis and mechanisms of inhibition, reactivation, and aging. Structure and catalytic properties of human natural BChE variants with respect to their sensitivity to drugs are also discussed.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
00220104
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb
Profili:
Zrinka Kovarik
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
Uključenost u ostale bibliografske baze podataka::
- Chemical Abstracts
- Chemical Abstracts
- Biological Abstracts
