Pregled bibliografske jedinice broj: 231056
Interleukin-8 concentrations in patients with severe head injury: comparison with ICP and CPP.
Interleukin-8 concentrations in patients with severe head injury: comparison with ICP and CPP. // Intensive Care Medicine (Supplement 3)
Rim, Italija, 2000. (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 231056 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Interleukin-8 concentrations in patients with severe head injury: comparison with ICP and CPP.
Autori
Mazul-Sunko, Branka ; Marout, Jasminka ; Novkoski, Mladen ; Širanović, Mladen ; Perić, Mladen ; Kelečić, Mijo ; Gopčević, Aleksandar
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Intensive Care Medicine (Supplement 3)
/ - , 2000
Skup
13 th Annual Congress of the European Society of Intensive Care Medicine
Mjesto i datum
Rim, Italija, 01.10.2000. - 04.10.2000
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
IL-8; head injury
Sažetak
INTERLEUKIN - 8 CONCENTRATIONS IN PATIENTS WITH SEVERE HEAD INJURY: COMPARISON WITH ICP AND CPP Mazul – Sunko B, Marout J*, Novkoski M, Širanović M, Perić M, Kelečić M, Gopčević A. Department of Anesthesiology and Intensive Care medicine and *Department of Endocrinology, Clinical Hospital “ Sestre milosrdnice” , Zagreb, Croatia. Introduction. Cytokines are involved in the pathophysiology of secondary brain damage after traumatic brain injury. They take part in cerebral edema formation, increased vascular permeability and neutrophil adhaesion. Interleukin-8 is believed to have a crucial role in this process1. Methods. We investigated the correlation between IL-8 and intracranial pressure, cerebral perfusion pressure and GCS score in 13 patients with severe head injury (GCS <= 8). All patients had a ventricular catheter inserted for therapeutic reasons. Blood samples for determining IL-8 were taken from the cerebrospinal drainage system and from both the cava and bulbus jugulare catheters. Intracranial pressure and cerebral perfusion pressure were noted on the patient list simultaneously with the taking of samples for determining IL-8. Interleukin-8 was analyzed using Milenia IL-8 endpoint enzyme Immunometric Assay, DPC LA, California. Normal value is < 31 pg/ml. The Pearson product moment correlation was used for stastistical analysis. Results. We analyzed results of 22 parallel measurements in 13 patients of IL-8 concentrations and clinical variables: ICP, CPP and GCS. 3. IL-8 from cava catheter is negatively correlated with GCS, r = - 0. 44, p < 0.04. 4. Cerebrospinal IL- 8 concentration is 15 times higher than in the serum from either the cava or bulbus jugulare catheter, but is not correlated with ICP or CPP. Mean cerebrospinal concentration of IL- 8 is 790 --+ 285 pg/ml, in blood from cava catheter it is 52 + - 45.97 pg/ml. Difference is significant at p < 0.0001. . Conclusions. 1. CORRELATION OF IL-8 AND GCS CONFIRMS ITS IMPORTANCE IN PATHOPHYSIOLOGY OF TRAUMATIC BRAIN INJURY. HIGH CORRELATION OF IL-8 WITH ICP IS CONSISTENT WITH EXPERIMENTAL INDICATIONS OF ITS ROLE IN BRAIN EDEMA FORMATION 2. 15 TIMES HIGHER CONCENTRATIONS OF IL-8 IN CEREBROSPINAL FLUID THAN IN SERUM, IMPLY ITS LOCAL PRODUCTION.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
KBC "Sestre Milosrdnice"
