Naslov
Comparative Genetic Toxicity of Some Pesticide

Autori
Franekić, Jasna ; Papeš, Dražena, Alačević, Marija

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Heavy metal dietary intake: A European comparison

Urednik/ci
Richardson, Mervyn

Izdavač
VCH Verlagsgesellschaft

Grad
Weinheim

Godina
1994

Raspon stranica
141-156

ISBN
3-527-28630-6

Ključne riječi
pesticides, genotoxicity, short-term tests

Sažetak
The extensive use of pesticides in modern agriculture requires for both the compatibility of these agents in the environment, and that public health requirements should be determined in order to ensure their chemical safety. Of particular importance is the potentially hazardous effects associated with the widespread application of pesticides. Genotoxic effects have been reported for many pesticides, including carbamates, organophosphates, and chlorinated hydrocarbons. A large number of genotoxicity tests re presently available for use in hazard evaluation. These tests detect the 2 main categories of mutations, gene mutation and chromosomal aberration, as well as indications of DNA damage. Tests to assess these endpoints can be carried out both in vitro and in vivo, eith in vivo tests being conducted in germ cells, as well as in somatic cells. In order to asses adequately any expression of genotoxicity, a systematic approach to the selection of these tests is required.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija

POVEZANOST RADA