Naslov
Induction of mitotic segregation by chloromethanes and chloroethanes in Aspergillus nidulans

Autori
Crebello, R. ; Franekić, Jasna ; Benigni, R. ; Conti, G. ; Conti, L. ; Carere, A.

Izvornik
Mutation Research (0165-1161) 203 (1988), 3; 223-223

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopćenje, znanstveni

Ključne riječi
mitotic segregation ; chloromethanes ; chloroethanes ; Aspergillus nidulans

Sažetak
Several chloromethanes and chloroethanes were assayed for their ability to induce mitotic segregation in A. nidulans. All tested chemicals turned out to be active, to various degrees, in a narrow range of concentrations. Active doses were immediately below the concentration arresting conidial germination and nuclear division. Among the halomethanes assayed, CCl4 was the most acitve (LEC 0.04% v/v), increasing up to 10-fold the spontaneous frequency of mitotic segregants. Chloroform and CH2Cl2 were similarly acitve (ca.5-fold increases) at higher concentrations (LEC 0.16 and 0.4%, respectively). Among the haloethanes, 1, 2-dichloroethane and 1, 1-dichloroethane showed identical cytotoxic and cytostatic properties and were active in the same range of concentrations (0.2-0.3%) but exerted different mutagenic protencies, the former increasing the spontaneous frequencies up to 30-fold and the latter being only borderline active. Mutagenic potencies of tested chemicals were poorly correlated with log P, melting point and MW but showed a significant correlation with the refractive index

Izvorni jezik
Engleski

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