Pregled bibliografske jedinice broj: 230001
Genotoxicity of nitrosated ranitidine
Genotoxicity of nitrosated ranitidine // Mutation Research, 227 (1989), 1; 13-16 doi:10.1016/0165-7992(89)90061-4 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 230001 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Genotoxicity of nitrosated ranitidine
Autori
Franekić, Jasna ; Skupnjak, Štefica ; Matijašević, Zdenka
Izvornik
Mutation Research (0165-7992) 227
(1989), 1;
13-16
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
ranitidine ; nitrite ; nitrosation in vitro ; Salmonella typhimurium ; Saccharomyces cerevisiae
Sažetak
The genotoxicity of ranitidine, widely used in the thrapy of peptic ulcers, and of nitrosated ranitidine was examined in test systems with the bacteria Salmonella typhimurium for gene mutations, and with the yeast Saccharomyces cerevisiae D7 for reverse mutations and gene conversion. Under the experimental conditions applied, ranitidine waas negative in both systems, while the product obtained by nitrosation in vitro was mutagenic for Salmonella trains TA100 and TA98 with and without metabolic activation. The largest increase of his+ revertants, 3 times greater than the control, was obtained in strain TA100 in the absence of S9 fraction. Nitrosated ranitidine was also recombinogenic for the yeast S. cerevisiae.
Izvorni jezik
Engleski
Znanstvena područja
Biotehnologija
POVEZANOST RADA
Ustanove:
Prehrambeno-biotehnološki fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
