╨╧рб▒с>■  /1■   .                                                                                                                                                                                                                                                                                                                                                                                                                                                ье┴q`Ё┐ХbjbjqPqP_::Х      дъъъъъъъ$ Ч Ў>>>>>       $Н hї>< ъz z z < ъъ>>█Q ┬ ┬ ┬ z тъ>ъ> ┬ z  ┬ ┬ ъъ┬ >2 pt╗Rvу┼\ :┬ Є $g 0Ч ┬ 3Ц 3┬ 3ъ┬ 0Zs@┬ │4чУ< < м Ч z z z z ъъъъъъ     аDOES HYPERCORTISOLISM ASSOCIATED WITH MAJOR DEPRESSIVE DISORDER MAY PLAY A ROLE IN THE PATHOGENESIS OF OSTEOPOROSIS? Vrkljan M, Matovinovic M, Maric A, Katinic K, Herman D, Cerina V Department of Endocrinology, Diabetes and Metabolic Diseases, " Sestre milosrdnice" University Hospital, 10000 Zagreb, Croatia In subjects with major depressive disorder (MDD) exist series of endocrinological and immunological disturbances which can lead to bone density decrease. Osteoporosis is the most common bone disease and its tendency of fracture is a huge problem. Pathogenesis of osteoporosis in patient with MDD is still a matter of debate. There are two well-documented biochemical abnormalities in MDD: hypercortisolism and its resistance to dexamethasone supression test (DST). Hypercortisolism causes low bone density by following manner: decreased Ca++ apsorption from intestine, gonadal steroids level and bone formation, and increased renal Ca++ excretion, PTH level and osteoclastic bone resorption. The study included 31 patients with MDD, 19 males and 12 females, (mean age 37+/-1.3, age range 29-41 years), and 17 healthy male volunteers (mean age 39+/-1.6, age range 34-45 years). In each of our patients 24-hour urinary free cortisol, serum cortisol level at 8 a.m. and 5 p.m., cortisol in DST and bone mineral density were measured. Analysis showed that increased levels of cortisol were associated with the occurence of osteoporosis. In our study we used nonparametric rang-correlation with SpearmanТs ro=-0.805, with statistic significant at the 0.01 level (2-tailed). Patients under long-term history of depression could develop a severe type of osteoporosis.  {┤╜=   ╙ Є ТУХю┌╞┌┬┌н┌Щ┌М┬hщ^уaJmH nH sH u&h№u╣B*^JaJmH nH phsH u)hщ^у6БB*^JaJmH nH phsH uhщ^у&h@БB*^JaJmH nH phsH u&hщ^уB*^JaJmH nH phsH u"hщ^уB*aJmH nH phsH u xyz{╝╜= > ? @ СТУє╧╧╧╧╧╧╔╧╧╧╧╧Ikd$$If╓0Ц└!ЦАЎИ6╓  ╓  ╓  ╓  3╓4╓aЎ$If# ╞2Ф(╝ Pфx а4 ╚#\'Ё*Д.2м5@9dЁ$If $dЁ$Ifa$Х¤УФХ¤¤,1Рh░╨/ ░р=!░"░#Ра$Ра%░░─░─ Р─/ 01Рh░╨/ ░р=!░"░#Ра$Ра%░░─░─ Р─g$$If!vh5╓Ц5╓*!#vЦ#v*!:V ЎИ6Ў,╓5╓Ц5╓3╓4╓ ЖЬH@ё HNormalCJ_HaJmHnHsHtH u>AЄ б> Zadani font odlomkaZi@є │Z Obi na tablica :V Ў4╓4╓ laЎ .kЇ ┴. Bez popisa дe@Єд HTML unaprijed oblikovano7 ╞2Ф(╝ Pфx а4 ╚#\'Ё*Д.2м5@9CJOJQJ^JaJmH sH uОB@О Tijelo teksta= ╞2Ф(╝ Pфx а4 ╚#\'Ё*Д.2м5@9dЁB*^JaJmH phsH uФХ    .    xyz{╝╜=>?@СТУФЧй0АА╨ й0АА╨й0АА╨й0АА╨й0АА╨й0АА╨й0АА╨й0АА╨й0АА╨й0АА╨й0АА╨й0АА╨й0АА╨ Щ0АА╘ IИ0АШ0ААХУХ Х Ё8Ё@ё   АААўЁТЁЁ0Ё( Ё ЁЁB ЁS Ё┐╦  ?Ё  ИT+4у ЙT+\└"КT+ДwЛT+фоМT+Й#НT+B --5№Ч%3<< ЧC*Аurn:schemas-microsoft-com:office:smarttagsАmetricconverterА9*Аurn:schemas-microsoft-com:office:smarttagsАplaceА=*Аurn:schemas-microsoft-com:office:smarttags АPlaceTypeА8*Аurn:schemas-microsoft-com:office:smarttagsАCityАB*Аurn:schemas-microsoft-com:office:smarttagsАcountry-regionА ,╢А8 a АProductID#$KLYZ{ГЖСХЪЮе│╣╩у√%&=@д║▐ь∙ёє СЧ{╗qv╝─Ч333{╗Ч│╣ЧхKv|@БмLа№u╣xтщ^уТУЧЦ @ А|JhХP@  Unknown            GРюЗz А Times New Roman5РАSymbol3&Рю Зz А Arial?5Рю Зz А Courier New"qИЁ╨hd:Ы&d:Ы&·ЄХ&√Ъ √Ъ !Ёа┤┤ББ4dТТД2ГЁ▄HPЁ ?т                     щ^у2   jureMilan■ рЕЯЄ∙OhлС+'│┘0|Шам╕╚╘рЁ   , 8 D P\dltт jureNormalMilan2Microsoft Office Word@@,Щqe┼@╩Gvу┼@╩Gvу┼√Ъ■ ╒═╒Ь.УЧ+,∙о0ь hp|ДМФ Ьдм┤ ╝ ╩тwin Тц  Naslov ■   ■   ■    !"#$%■   '()*+,-■   ¤   0■   ■   ■                                                                                                                                                                                                                                                                                                                       Root Entry         └Fpt╗Rvу┼2АData              1Table    3WordDocument    _SummaryInformation(            DocumentSummaryInformation8        &CompObj            s            ■                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           ■       └F!Microsoft Office Wordov dokument MSWordDocWord.Document.8Ї9▓q