Naslov
Alpha-fetoprotein and free beta chorionic gonadotropin as markers in biochemical screening for Down's syndrome and neural tube defects

Autori
Tišlarić, Dubravka ; Košec, Vesna ; Petek, Marijan ; Relja, Zoran ; Rušinović, Frane ; Ujević, Boris ; Miljan, Mladen

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Clinical Chemistry and Laboratory Medicine / Gerard Siest, Marek H. Dominiczak - Berlin : Walter de Gruyter, 1999

Skup
IFCC-WorldLab 17th International and 13th Europian Congress of Clinical Chemistry and Laboratory Medicine

Mjesto i datum
Firenca, Italija, 06.06.1999. - 11.06.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
Down's syndrome; alpha-fetoprotein; free beta-hCG

Sažetak
OBJECTIVE: The evaluation of prenatal screening for Down's syndrome (DS) and neural tube defects (NTD), using alpha-fetoprotein (MS-AFP) and free beta chorionic gonadotropin (F-beta hCG) as biochemical markers. MATERIAL AND METHODS: The study was performed in 1185 women (13-21 gestational week). Serum markers were determined by immuno-radiometric assays (CIS, France). The calculation of individual risks was performed by the computer software ("Free-beta screen"). A patient was considered screen-positive for DS if the calculated risk was >/=1:250 ; MS-AFP >/= 2, 0 MoM was considered screen-positive for NTD. RESULTS: Out of 1185 women, 720 (60, 8%) were younger, and 465 (39, 2%) older than 35, respectively. A total of 130 (10, 9%) were DS screen-positive. The false-positive rate was 4% in younger and 20, 6% in older than 35, respectively. Five Down-syndrome fetuses were fund prenatally, three of them in women younger than 35. There were 20 (1, 7%) NTD screen-positive pregnancie, two babies have structural abnormalities confirmed by ultrasound. The perinatal oucome was ascertained in all tested pregnancies. CONCLUSION: Current results support the value of biochemical screening, particularly in younger population of pregnant women. Considering those older than 35, it could serve as a screening test according to the specific clinical circumstances and patient's individual choice or belief after being informed about the test.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA