Naslov
Regulatory T Cells In Systemic Lupus Erythematosus: A Case Report

Autori
Marinić, Igor ; Cepika, Alma-Martina ; Gagro, Alenka ; Rabatić, Sabina ; Morović-Vergles, Jadranka ; Soldo-Jureša, Dragica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract book, Annual meeting of the Croatian immunological society 2005 / - Rijeka, 2005

Skup
Annual meeting of the Croatian Immunological Society 2005

Mjesto i datum
Božava, Dugi otok, Hrvatska, 29.09.2005. - 02.10.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
regulatory T cells; systemic lupus erythematosus; autoimmune diseases

Sažetak
Regulatory T cells (Tregs) contribute to the maintenance of peripheral tolerance and therefore are important in various clinical conditions including autoimmune disorders. This population exerts its suppressive effect on neighboring immune cells, contributing to local modulation and restriction of the immune response. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease seen predominately in young women. The disease is accompanied with damage of multiple organ systems. Recently it has been shown that the Treg levels in SLE patients are lower than in healthy individuals. In this preliminary study we investigated the effect of corticosteroid therapy in a newly diagnosed SLE patient. The peripheral blood samples were obtained from the patient before and three weeks after the beginning of corticosteroid therapy. Cells were stained with CD3, CD4, CD25 and Foxp3 fluorochrome-labeled monoclonal antibodies using four-color immunofluorescence staining protocol, and then analyzed on a flow cytometer. We confirmed that the percentage of CD4+CD25high cells was lower in SLE patient than in healthy control group. Results showed that the percentage of regulatory T cells expressing Foxp3 after three weeks of corticosteroid therapy increased to levels observed in age- and gender-matched healthy controls. The increase was accompanied with improvement of patient's clinical status. These results are consistent with previous study in asthma, which showed that corticosteroid therapy might increase the number of regulatory T cells. For confirming this, further studies on a larger population are currently underway.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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