Naslov
Genetic relationships between speed of greying, melanoma and vitiligo prevalence in grey horses

Autori
Sölkner, J ; Seltenhammer, M ; Čurik, I ; Niebauer, G

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Final programme and book of abrstract Second congress of Croatian geneticists / Franekić Čolić, Jasna ; Ugarković, Đurđica - Zagreb : Hrvatsko genetičko društvo, 2005

Skup
Second congress of Croatian geneticists

Mjesto i datum
Supetar, Hrvatska, 24.09.2005. - 27.09.2005

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
grey horses; melanoma and vitiligo prevalence in grey horses

Sažetak
Grey horses are born with a dark coat and change coat colour into white in a process of premature greying of the hair. A specific form of melanoma is very frequent in grey horses, about 75 percent of horses older than 15 years are diagnosed with some stage of melanoma. Much has been speculated about a relation between early greying and the prevalence of melanoma. Vitiligo (patches of depigmented skin) is also not unusual in grey horses. The quantitative inheritance of grey level, melanoma and vitiligo prevalence was analyzed on 877 Lipizzan horses born in five state studs (Austria, Croatia, Hungary, Slovakia and Slovenia). Melanoma status (levels 0-5) was recorded for 6 years, greying level (L* parameter of the CIE L*a*b system) for 4 years and vitiligo status (levels 0-3) for 2 years. Heritabilities and genetic correlations were estimated by multivariate animal model REML. As differences in speed of greying are expressed at young ages whereas melanoma and vitiligo tend to develop at later ages, data for level of greying (739 obs.) were restricted to ages of 1-6 years, whereas data on melanoma (1186 obs.) and vitiligo (650 obs.) were only included for horses older than 6 years. Estimated heritabilities were 0.75&plusmn ; 0.05 for level of greying, 0.31&plusmn ; 0.05 for melanoma status and 0.44&plusmn ; 0.06 for vitiligo status. The genetic correlation between speed of greying and vitiligo was high (0.61&plusmn ; 0.07), whereas the others were only slightly positive (0.14&plusmn ; 010, each). The size of heritabilitiy for all traits warrants further studies trying to dissect the underlying genetic mechanisms at the molecular level. A first attempt will include the dominant gene responsible for the greying process which is currently being described by other groups.

Izvorni jezik
Engleski

Znanstvena područja
Poljoprivreda (agronomija), Biotehnologija

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