Naslov
Higher sensitivity of CA1 sznapses to aglycemia in streptozotocin-diabetic rats is age-dependent

Autori
Tekkok, Selva ; Križ, Jasna ; Pađen, Ante ; Krnjević, Krešimir

Izvornik
Brain research (0006-8993) 813 (1998), 2; 268-273

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
adenosine; peripheral nerves; conduction velocity; rheobase and chronaxie; young and old

Sažetak
We studied conduction velocitz in peripheral nerves and the block of sznaptic transmission produced bz lack of glucose in hippocampal slises from 4 and 12 month old STZ-induced diabetic rats and their age-matched controlsIn sural nerves of zoung and old diabetic rats the conduction velocity was reduced by 30-35%. In slices from young diabetics CA1 sznaptic transmission was more sensitive to aglycemia, than in control slices. However, all slices from older rats showed comparable increase in CA1 synaptic sensitivity to aglzcemia. We conclude that the cerebral adaptation to diabetic hzperglzcemia apparent in hzppocampus of zoung eats is masked in older rats by an age-dependent increase in sensitivity to lack of glucose

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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