Naslov
Significance of Helicobacter pylori eradication in the treatment of gastroesophageal reflux disease

Autori
Tićak, Mirjana ; Katičić, Miroslava ; Škurla, Bruno ; Prskalo, Marija ; Šabaric, Branka ; Čolić-Cvrlje, Vesna ; Filipec-Kanižaj, Tajana ; Naumovski-Mihalić, Slavica ; Papa, Branko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Helicobacter / Graham, David, J - Houston (TX) : Blackwell Publishing, 2005

Skup
The XVIIIth international workshop on gastrointestinal pathology and Helicobacter.

Mjesto i datum
Kopenhagen, Danska, 12.10.2005. - 14.10.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Helicobacter pylori; GERD; dyspepsia
(Helicobacter pylori; GERB; dispepsija)

Sažetak
Aim: To determine the effect of eradication of Helicobacter pylori infection on subjective symptoms in patients with GERD. Material and methods: A total of 110 patients with diagnosed GERD were included in the study. Of 65 patients with H. pylori infection, eradication therapy was performed in 35 (the success rate 90% ; 7-day therapy with pantoprazole, amoxicillin, clarithromycin) and 45 patients tested negative for H. pylori. All patients received pantoprazole for 4 weeks. Severity of subjective symptoms was evaluated with the Nepean Dyspepsia Index at baseline and after 1 month of treatment. Statistical analysis was performed using analysis of variance. Results: In all three groups of patients with GERD (H. pylori-positive eradicated, H. pylori-positive non-eradicated, and H. pylori-negative), a statistically significant decrease in dyspeptic symptoms was reported (p<0, 01). No statistically significant differences were discovered in decrease in dyspeptic symptoms between the groups (p>0, 05). Conclusion: 1. Eradication of H. pylori infection in patients with GERD was not found to statistically significantly influence the decrease of subjective symptoms, the patients with eradicated and non-eradicated H. pylori infection experience a similar decrease ; 2. H. pylori infection does not have a statistically significant influence on symptoms decrease in patients with GERD, the patients with non-eradicated H. pylori infection and H. pylori-negative patients have decreased to an approximately same extent ; 3. statistically significant decrease in symptoms in all three groups of patients is result of IPP therapy.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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