Naslov
BLOOD PRESSURE-KIDNEY VOLUME RELATIONSHIP IN ESSENTIAL HYPERTENSION: P2.242.
(Blood pressure – kidney volume relationship in essential hypertension)

Autori
Laganović M ; Jelaković, Bojan ; Kuzmanić D ; Boršo G ; Rončević T ; Vdović M ; Željković T ; Kašner M ; Šmuc, Tomislav ; Gamberger, Dragan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Journal of Hypertension, Supplement / - , 2004, S220-s220

Mjesto i datum
,

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
krvni tlak; volumen bubrega
(blood pressure; kidney volume)

Sažetak
Objective: our aim was to analyze whether kidney volume (KV) determines blood pressure (BP) levels in essential hypertensives and healthy controls, whether lower birth weight (BW) contributes future hypertension through lower KV and whether microalbuminuria (MA) could be a marker of this pathway. Patients and methods: we included 103 patients (60 M, 30 F, age 37+9.1 years) with newly diagnosed essential hypertension (HT) and 92 healthy controls (NT) (47 M, 45 F, age 35+7.5 years). BP was measured using mercury sphygmomanometer and with ambulatory BP monitor. KV was determined by ultrasound using an ellipsoid formula and corrected for BSA (CorrKV). BW was obtained from mothers. MA was determined in 24h urine sample with nephelometric method Results: HT had higher weight, BMI, BSA(p < 0.001), lower BW, higher MA (p=0.01), higher sodium in 24 h urine (p=0.004) than in NT group. HT had shorter and widther kidneys and larger KV (p < 0.05). However, when corrected for BSA, the observed corrrelation was not statistically significant (p=0.13). We did not observe correlation between CorrKV and BP in both groups (p > 0.05). HT with lower BW (< 3000 g) had higher BP (p=0.03) than HT with normal BW. We found negative correlation between BW and BP (r = -0.31 ; p < 0.05 vs. r = -0.18 ; p < 0.05) in both groups. BW was not correlated with CorrKV except in HT with lower BW (r=0.64, p < 0.05). Both HT and NT with lower BW had thinner kidneys (p=0.02). We observed positive correlation between 24h sist. BP and MA (r=0.46, p < 0.05). BW and CorrKV were not correlated with MA (p > 0.05). However, increasing correlation was found between 24h sist BP and MA in subgroups with lower BW (< 3000 g. r=0.52, p < 0.05 ; <2500 g. r=0.60, p < 0.05). Conclusions: we failed to find association between KV and BP values. BW influences BP values in adult age but it was not mediated through lower KV. Participants with lower BW had thinner kidneys than normal BW group. MA is marker of early renal damage especialy in HT with lower BW. Other mechanisms (i.e. increased BMI, increased salt intake, etc) might be more important for increased BP.

Izvorni jezik
Engleski

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