Naslov
Hiperkalijemia i blokada renin-angiotenzinskog sustava kod bolesnika na hemodijalizi
(HYPERKALEMIA AND BLOCKADE OF RENIN-ANGIOTENSIN SYSTEM IN CHRONICALLY HEMODIALYZED PATIENTS)

Autori
Zibar, Lada ; Barbić, Jerko ; Milas-Ahić, Jasminka ; Jakić, Marko ; Galić, Andrea ;

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract book / - , 2005

Skup
Fifteenth European Meeting on Hypertension

Mjesto i datum
Milano, Italija, 17.06.2005. - 21.06.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
hiperkaliemija; hemodijaliza; ACE
(Hyperkaliemia; Haemodialysis; ACE)

Sažetak
Objective: Examination of increased risk of hyperkalemia in chronic hemodialysis (HD) patients upon blockade of the renin-angiotensin system by angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers. Patients and methods: Study included 194 chronically hemodialyzed patients (82 women, 112 men), mean age 59&plusmn ; 13 years, treated by HD for median time of 4 years (from 1 to 27 years). They underwent predialysis serum potassium concentration determination every 2 months for 5 times. Mean and maximal patient's potassium was analyzed. Hyperkalemia was defined by mean serum potassium concentration of more than 5.5 mmol/L. Medication was recorded from medical data and checked by patient interview. There were 63 patients treated by angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers. Results: Patients receiving ACE inhibitors or angiotensin receptor blockers did not have significantly higher mean or maximal potassium serum concentration in comparison with the patients without such therapy (Mann-Whitney test, z=-1.015, p=0.310 ; z=-0.325, p=0.745, resp.). The patients receiving this medication were not at increased risk for hyperkalemia (OR 0.812, 95%CI 0.444-1.485). Conclusion: Potassium excess in chronically hemodialyzed patients was not additionally worsened by angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers therapy. The results encourage their use in HD patients. However, close potassium monitoring remains mandatory.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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