Naslov
Vitamin C u plazmi i urinu shizofrenih bolesnika.
(Plasma Levels and Urinary Vitamin C Excretion in Schizophrenic Patients)

Autori
Subotičanec, K. ; Folnegović-Šmalc, V., Turčin, R., Meštrović, B., Buzina, R.

Izvornik
Human nutrition. Clinical nutrition (0263-8290) 40 (1986), C; 420-428

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
shizofrenija; vitamin C; plazma; urin
(schizophrenia; vitamin C; placma; urine)

Sažetak
Vitamin C status was determined schizophrenic subjects using fasting plasma levels and the urinary dose response after an oral load of 1, 0 g ascorbic acid. The study was carried out in 20 schizophrenic patients and 15 controls with the diagnosis of neurosis who were on the same hospital diet for at least 2 months. The schizophrenic subjects had significantly lower fasting plasma vitamin C levels (P<0, 05) and 6-h urinary vitamin C excretion after an ascorbic acid load test (P<0, 01). Since urinary vitamin C excretion in both groups was significantly associated with differences in fasting vitamin C plasma levels (P<0, 001), a new group of 15 schizophrenics and 15 controls was supplemented with 70 mg of ascorbic acid daily for 4 weeks in order to optimize and standardize their vitamin C plasma levels before the ascorbic acid loading test. The results showed that after 4 weeks of supplementation the average fasting plasma vitamin C levels were almost identical in both examined groups, but the urinary vitamin C excretion was again significantly lower in schizophrenic patients (P<0, 05). These results are in agreement with the hypothesis that schizophrenia may be associated with impaired ascorbic acid metabolism.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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