Naslov
Effect of smoking and Helicobacter pylori on prostaglandin concentrations in gastric and duodenal mucosa of patients with duodenal ulcer and duodenitis

Autori
Bago, Josip ; Renić, Marija ; Kučišec, Nastja ; Čulo, Filip ; Bilić, Ante ; Eljuga, Damir ; Jurčić, Dragan

Izvornik
Collegium Antropologicum (0350-6134) 21 (1997), 2; 507-515

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
smoking; Helicobacter pylori; prostaglandin; ulcer; duodenitis

Sažetak
The aim of this study was to determine the level of endogenous prostanglandin E2 (PGE2), prostanglandin F2alpha (6-keto-PGF1alpha) and thromboxane B2 (TXB2) in the gastric and duodenal mucosa of patients with duodenal ulcer and duodenitis. Besides, the investigation aimed at determining the effect of smoking and infection by Helicobacter pylori on prostanglandin synthesis. The investigation comprised 62 patients with duodenal ulcer, 46 patients with duodenitis and 44 controls. The result of our investigation indicate that the decreased prostanglandin synthesis in gastric and duodenal mucosa determined in patients with duodenal ulcer may have a considerable role in development of duodenal ulcer. Futhermore, the harmful effects of smoking on the gastric and duodenal mucosa may be mediated by the decreased prostanglandin synthesis in the gastric and duodenal mucosa. However, Helicobacter pylori seems to affect the development of duodenal ulcer through other mechanisms.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

POVEZANOST RADA