Naslov
Effects of gamma-amino-beta-hydroxy butyric acid (GABOB) on growth hormone (GH) release in patients with prolactinoma

Autori
Tepavčević, Danilo ; Mikuličić, Vanja ; Jelić, Tomislav ; Giljević, Zlatko ; Kopjar, Branko ; Suchanek, Ernest ; Kožić, Blaženka ; Koršić, Mirko ; Plavšić, Vesna

Izvornik
Advances in the biosciences (0065-3446) 69 (1988); 335-336

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
GABOB; Growth hormone; Prolactinoma

Sažetak
The influence of orally administered GABOB on GH secretion has been studied in 39 normal volunteers and 30 patients with prolactinoma. In normal subjects the 5 g dose of GABOB increased serum GH levels from basal 0.409 +/- 0.029 ng/ml (mean +/- SEM) to a peak of 19.7 +/- 2.11 ng/ml at 90 min (p<0.001). In 17 patients with microprolactinoma the same dose of drug increased GH levels from basal 0.405 +/- 0.054 ng/ml to a peak of 13.2 +/- 2.56 ng/ml at 90 min (p<0.001), while in 13 patients with macroprolactinoma there was no change (basal 0.685 +/- 0.146 ng/ml vs. a peak of 0.782 +/- 0.119 ng/ml ; p>0.5). In conclusion, our results demonstrated a differential effect of GABOB on GH release in patients with prolactinoma, that may contribute to better delineation of these lesions.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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