Naslov
Dopamine antagonists induce gastric lesions in rats

Autori
Sikirić, Predrag ; Geber, Juraj ; Ivanović, Dragutin ; Suchanek, Ernest ; Gjuriš, Veljko ; Tućan-Foretić, Milica ; Miše, Stjepan ; Cvitanović, Branimir ; Rotkvić, Ivo

Izvornik
European journal of pharmacology (0014-2999) 131 (1986), 1; 105-109

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Dopamine antagonists; Gastric lesion; Dopamine agonists; Dopamine

Sažetak
Gastric lesions were provoked in all rats that had received intraperitoneally a single dose of the dopamine antagonists haloperidol, metoclopramide or domperidone 24 h before. Dose-dependence was demonstrated for haloperidol. This drug induced gastric lesions as early as 90 min after its application. The ulcerogenic effect of haloperidol was completely prevented or markedly reduced by simultaneous applications of dopamine agonists bromocriptine or L-dopa. We conclude that the model of gastric lesions induced by dopamine antagonists could be successfully applied in further investigations of the role of dopamine in the pathogenesis of ulcer disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA