Naslov
Quantitative study on the rat parotid gland after orchiectomy

Autori
Ježek, Davor ; Banek, Ljerka ; Pezerović-Panijan, Ružica ; Pezerović, Džemal

Izvornik
Veterinarski arhiv (0372-5480) 69 (1999), 1; 49-59

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
rat; parotid gland; orchiectomy; stereology

Sažetak
In this study, the reaction of the rat parotid acini, duct system and the glandular connective tissue at various times after orchiectomy was analysed. Mature Fisher rats were sacrificed 12 hours and 3, 8, 15, 30 and 60 days after orchiectomy. Following the removal of parotid glands, histological sections were made and stereologically analysed by Weibel*s multipurpose test system. When compared to controls, the volume of the parotid acini (per mm3 of the tissue) in orchiectomized rats was significantly decreased, whereas the volume of the connective tissue (per mm3 of the tissue) was significantly increased from day 8 to day 60 of the experiment. The significantly lower volume of the ductal system (per mm3 of the tissue) was noted only 60 days after orchiectomy. The statistically significant shortening of the intralobular ducts (per mm3 of the tissue) was found from day 8 to day 60 after the operation. The interlobular ducts were significantly shorter from day 8 to day 15 after orchiectomy. The shortening of the rat parotid duct system and the changes of the parotid acini and the connective tissue after orchiectomy may be provoked by the lack of testosterone or some other substance which depends on androgens, like epidermal growth factor (EGF).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA