Naslov
Clinical and electrophysiological assessment of children with axonal variants variants of Guillain Barre syndrome (GBS)

Autori
Barišić, Nina ; Lehman Ivan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
European Journal of paediatric Neurology. Abstracts for the 5th International Congress of the European Paediatric Neurology Society. / - , 2003

Skup
5th International Congress of the European Paediatric Neurology Society

Mjesto i datum
Taormina, Italija, 22.10.2003. - 25.10.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
neurography; children; GBS; axonal

Sažetak
GBS spectrun includes acute inflammatory demyelinating polyneuropathy (AIDP), pure motor or sensory motor (AMAN, AMSAN) or bulbar variants and Miller Fisher syndrome. Axonal form is associated with the more severe course and poor recovery. Inexcitable nerves is rare neurographic feature in the early course of GBS. We<studied two children with GBS at tha age 12 and 35 months. Children were examined clinically and/or electromyoneurographically 2-6 times during 6 months...6 years of follow up. First electromyoneurography (EMG) was performed in the period 5-30 days after the inital symptoms occurred. Generalized inexcitable nerves and spontaneous activity were present while neural potentials and F waves were absent initially in both children. Both children were quadriplegic (MRC 0-1). 1/2 required prolonged mechanical ventilation. Brain and spinal MR were normal in 2/2. Severe clinical course with early muscle wsting was registered in both children. Clinically discrete monoparesis remained in one child with hyperreflexia and positive Babinski sign on follow up examination, while the other is still not ambulant after 6 months of treatment. (MRC3). Poor outcome with inexcitable nerves and muscle wasting early in the course of GBS indicate massive axonal loss although severe demyelination and secobdary axonal damage may resemble clinically and electrophysiologically to "axonal" variant of GBS with central nervous system (CNS) involvement.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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