Naslov
Plasma beta-endorphin concentration in depressed newborns at term

Autori
Škrablin-Kučić, Snježana ; Halimi, Setar ; Čorušić, Ante ; Suchanek, Ernest, Kuvačić, Ivan ; Hodžić, Damir

Izvornik
Journal of maternal-fetal investigation (0939-6322) 4 (1994); 103-106

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Beta-endorphin; Neonatal depression; Labor; Fetal acidosis

Sažetak
Objective: The concentration of beta-endorphin in umbilical arterial blood was related to plasma acid-base parameters, type of acidosis, and neonatal health immediately after delivery, to reveal whether fetal acidosis and later, neonatal depression, were associated with elevated levels of beta-endorphin. Methods: Twenty-six, vaginally delivered infants, chosen at random, were studied. In 11 of 26 (42.3%) umbilical artery pH was under 7.20 and 6 of 26 (23.1%) were considered as having signs of neonatal depression, defined as a need for additional oxygenation because of decreased respiratory drive at least during the first day of life. Arterial cord blood samples were collected at delivery for acid-base and beta-endorphin determinations. Neonatal acidosis, if present, was classified furher as metabolic, respiratory, or mixed. Conclusions: Plasma beta-endorphin concentration in newborn umbilical artery at delivery might be considered as a consequence of fetal stress reaction during labor, with elevated levels in acidosis. It could be speculated that high beta-endorphin levels might prevent acidotic infants from getting rid of excess carbon dioxide, thus causing neonatal respiratory depression,

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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