Naslov
Children At Risk Of Premature Atherosclerosis

Autori
Krželj, Vjekoslav ; Zanchi, Jakša ;

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
29th UMEMPS Congress, Union of Middle Eastern and Meditterranean Pediatric Societies ; Abstract book / Hasanoglu, Enver ; - Istanbul, 2005

Skup
29th UMEMPS Congress, Unoin of Middle Eastern and Meditterranean Pediatric Societies ;

Mjesto i datum
Istanbul, Turska, 14.09.2005. - 17.09.2005

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
-

Sažetak
Objectives: Atherosclerosis is a life long process, which originates early in the childhood. It is a very complex disease depending from mutual interaction of genetic endowment and environmental influences. Although hypercholesterolemia is the most important risk factor for atherosclerosis other non lipid risk factors such as obesity, high blood pressure, diabetes, physical inactivity, consumption of a high energy, cigarette smoking, parental history of premature cardiovascular disease, have also a great impact on development of atherosclerotic disease. It is obvious that as the number of cardiovascular risk factors increases so does the risk of atherosclerosis beginning in childhood. The cornerstone of treatment for hyperlipidemia is dietary alteration. Genetic factors may modulate dietary effects of lipid metabolism. The combination of diet and drugs enables some children to achieve lipid goals not achieved with diet alone. Method and results: So far as cholesterol screening is concerned it remains a matter of debate. Our recent study among 1753 adolescent boys showed that 13, 4% of them had total cholesterol level at or above the risk cut-off of 5, 2 mmol/L. Parental history of premature cardiovascular disease or hyperlipidemia was not a good predictor of children with elevated cholesterol levels. Conclusion: We recommend universal cholesterol screening in childhood based on the LDLC level. Early identification and treatment of childhood hyperlipidemia should further reduce the excessive number of disability and death attributed to coronary heart disease.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA