Naslov
Screening for Down's syndrome and neural tube defect in Croatia : A regional prospective study

Autori
Brajenović-Milić, Bojana ; Tišlarić, Dubravka ; Bačić, Josip ; Paravić, Jadranka ; Slivar, Anđelo ; Kapović, Miljenko ; Košec, Vesna ; Ristić, Smiljana ; Rajhvajn, Branko

Izvornik
Fetal diagnosis and therapy (1015-3837) 13 (1998); 367-371

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Down's syndrome screening; alpha-fetoprotein; free beta-human chorionic gonadotropin

Sažetak
The purpose of this study was to investigate the efficiency of second-trimester maternal screening for Down's syndrome and open neural tube defects using alpha-fetoprotein and free beta-human chorionic gonadotropin as serum markers. 3, 188 women underwent testing between 14th and 22nd week of pregnancy. Of all tested patients, 25, 4% were > or = 35 years old. A cut-off risk of >/=1:250 for Down's syndrome and MS-AFP >/=2, 0 MoM for open neural tube defect were considered screen-positive. The detection rate for Down's syndrome was 77, 8% (7/9) with 8, 2% screen-positive rate (7, 9% false-positive rate). When evaluated separately, in patients younger than 35 and in those >/= 35 years old, the screen-positive rates were 3, 1 and 23, 3 %, respectively. A total of 52 (1, 6%) were found screen-positive for open neural tube defect. ; 2 cases of encephalocela and 1 case of gastroschisis were confirmed prenatally. The respectable number of cases with trisomy 21 identified in this study confirmes that routine mid-trimester screening for Down's syndrome including MS-AFP, free beta-hCG and maternal age is useful in identifying pregnancies at increased risk.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA