Pregled bibliografske jedinice broj: 221890
Calmodulin Kinase II Constitutively Binds, Phosphorylates, and Inhibits Brush Border Na+/H+ Exchanger 3 (NHE3) by a NHERF2 Protein-dependent Process
Calmodulin Kinase II Constitutively Binds, Phosphorylates, and Inhibits Brush Border Na+/H+ Exchanger 3 (NHE3) by a NHERF2 Protein-dependent Process // The Journal of biological chemistry, 287 (2012), 13442-13456 (podatak o recenziji nije dostupan, članak, znanstveni)
CROSBI ID: 221890 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Calmodulin Kinase II Constitutively Binds,
Phosphorylates, and Inhibits Brush Border Na+/H+
Exchanger 3 (NHE3) by a NHERF2 Protein-dependent
Process
Autori
Žižak, Mirza ; Bartoniček, Dorotea ; B. Cha ; Murtazina, R. ; Korać, J. ; M. Tse ; M. Donowitz
Izvornik
The Journal of biological chemistry (0021-9258) 287
(2012);
13442-13456
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
NHE3 ; CaM KII ; NHERF2 ; regulation ; phosphorylation ; binding
Sažetak
1) NHE3 is a CaM kinase II and Ca2+/CaM binding protein. 2) CaM kinase II binds to NHE3 under basal conditions, at aa 585-605. 3) CaM kinase II dependent phosphorylation of NHE3 inhibits NHE3 under basal conditions and this inhibition is mediated by NHERF2. 4) Ca2+/CaM also binds NHE3 under basal conditions at aa 585-605. CaM kinase II and Ca2+/CaM are part of the physiologic NHE3 regulation that occurs in fibroblasts as well as in BB of ileal Na absorptive cells.
Izvorni jezik
Engleski
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
