Naslov
Extremely altered non-specific bronchial reactivity in a moderate asthmatic patient after nasal challenge

Autori
Plavec, Davor ; Godnić-Cvar, Jasminka ; Kovač, Silvija ; Kanceljak, Božica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Knjiga sažetaka / Čikes, Nada - Dubrovnik : Hrvatsko društvo za alergologiju i kliničku imunologiju, 1998

Skup
Godišnji sastanak Hrvatskog društva za alergologiju i kliničku imunologiju

Mjesto i datum
Dubrovnik, Hrvatska, 15.10.1998. - 17.10.1998

Vrsta sudjelovanja
Demonstracija

Vrsta recenzije
Domaća recenzija

Ključne riječi
Occupational; rhinitis; asthma; bronchial provocation; nonspecific bronchial responsiveness; nasal provocation; histamine

Sažetak
JR, male, 40yrs, nonsmoker, 16 yrs of occupational exposure to organic solvents, acrylates and diisocyanates as a car painter. Has a moderate asthma for a year. Asthma attacks induced by exercise and occupational exposure. Has also the symptoms of conjuctivitis and rhinitis. Th. salbutamol MDI. Has a negative family history for asthma or atopy. Positive skin prick test to Dermatophagoides pt.- negative (<0,35kU/L). Nonspecific bronchial reactivity on three separate occasions PC20FEV1 from 0,125 to 0,5 mg/ml of histamine. Nonspecific nasal reactivity PC75NAR=4 mg/ml of histamine. Nonspecific bronchial reactivity measured on two separate occasions after nasal chalenge was significantly altered to PC75FEV1=4 mg/ml of histamine. We discuss the mechanism of such alteration in view of the results of our previous studies which show that it is probably mediated via reflex activation of presinaptic beta2-receptors in bronchi. In this patient pre-existing blockage of M2 muscarinic receptors by eosinophil mediators (MBP, EPO) could enhance the alteration of bronchial reactivity seen in healthy subjects.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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