Naslov
Significance of Measurement Value of Serum Alpha-feto Protein in Child with Germ Cell Tumor. Case Report

Autori
Lenicek Krleza, Jasna ; Stepan, Jasminka ; Nakic, Melita ; Zizic, Vesna

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Clinical Chemistry and Laboratory Medicine / - Berlin : New York : Walter de Gruyter, 2004

Skup
International Swiss MedLab and 8th Alps-Adria Congress 2004.

Mjesto i datum
Luzern, Švicarska, 05.10.2004. - 09.10.2004

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
alpha-feto protein; germ cell tumor

Sažetak
Aim of Report: Stress importance of value of serum alpha fetoprotein (AFP) in child with germ cell tumor. Patient: Eight months old girl was performed routine ultrasound due to congenital abnormalities in urogenital system – ureterocoela. During this procedure in pelvis was find heteroechogenic tumor mass which probably make problems with urine derivation. We find also the high value of alphafetoprotein (>16 000 ng/ml). Tumor was at this time inoperable, surgeon performed only punction biopsy and cytology was confirmed diagnosis of germ cell tumor. After confirmation of diagnosis we started with neoadjuvant chemotherapy – after three of VIP (vincristin-iphosphamide-cis-platinum) protocol (reduction protocol – 80% therapeutic dose) we had reduction of tumor size and infiltration of neighbour tissues. The value of serum alpha-feto protein was measured before cycle, at the end of cycle and one time per week during treatment. At the end of third cycle we had normal value of alphafetoprotein (9.71 ng/ml). After imaging – ultrasound with color doppler and computed tomography surgeon confirmed the necessity of tumor removal. Pathohistology confirmed germ cell origin of tumor. Postoperatively we have still normal value of alpha-fetoprotein (7.47 ng/ml). We will continue with three cycle of chemotherapy. Conclusion: Measurement of alpha-fetoprotein in our patient is important for confirmation of diagnosis, observation of treatment success and definition of time when tumor will be remove. We have to continue the measurment during postoperative chemotherapy and control period due to sensitivity of that tumor marker.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA