Naslov
Platelet activity in PTSD

Autori
Vidović, Anđelko ; Vilibić, Maja ; Markotić, Alemka ; Sabioncello, Ante ; Gotovac, Katja ; Folnegović-Šmalc, Vera ; Dekaris, Dragan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of Annual Meeting 2005 of Croatian immunological society / Jonjić, Stipan - Rijeka, 2005

Skup
Annual Meeting of the Croatian Immunological Society 2005

Mjesto i datum
Božava, Hrvatska, 29.09.2005. - 02.10.2005

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
posttraumatic stress disorder; PTSD; platelets; aggregates; flow cytometry

Sažetak
The evidence linking exposure to traumatic stress and cardiovascular disease is compelling and is supported by different epidemiologic studies. Platelets play a crucial role in the evolution of acute coronary syndromes and an exaggerated platelet activity has been shown to be associated with a higher incidence of acute coronary events. It is tempting to hypothesize that PTSD (post traumatic stress disorder) may confer a heightened platelet activity. This association might be formed through increased sympathetic output associated with PTSD. To investigate this possibility, we assessed platelet function in 20 Croatian war veterans with PTSD and 19 age matched healthy controls. Whole blood flow cytometry was used to determine percentage of CD63 positive (activated) platelets and percentages of monocyte-, granulocyte- and lymphocyte-platelet aggregates in unlysed, unwashed whole blood. Soluble P-selectin levels will be determined by ELISA in sera of participants. This pilot study showed that there are no differences between studied groups in any of measured parameters. However, as monocyte-platelet aggregates tend to be higher in PTSD patients, we performed the power analysis showing that bigger sample sizes would be needed for such a difference to be significant. Monocyte-platelet aggregates provide very sensitive measurement of platelet function and are susceptible to various confounding factors. It would still remain unclear if difference of this size is of any biological importance.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA