Naslov
A single air dive reduces arterial endothelial function in man

Autori
Brubakk, Alf O. ; Duplančić, Darko ; Valić, Zoran ; Palada, Ivan ; Obad, Ante ; Baković, Darija ; Wisloff, Urlik ; Dujić, Željko

Izvornik
Journal of Physiology (London) (0022-3751) 566 (2005), 3; 901-906

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
diving; decompression; venous gas bubbles; endothelial arterial function; human

Sažetak
During and after decompression from dives, gas bubbles are regularly observed in the right ventricular outflow tract. A number of studies have documented that these bubbles can lead to endothelial dysfunction in the pulmonary artery but no data exist on the effect of diving on arterial endothelial function. The present study investigated if diving or oxygen breathing would influence endothelial arterial function in man. A total of 21 divers participated in this study.Nine healthy experienced male diverswith ameanage of 31± 5 years were compressed ina hyperbaric chamber to 280 kPa at a rate of 100 kPa min− 1 breathing air and remaining at pressure for 80 min. The ascent rate during decompression was 9 kPa min− 1 with a 7 min stop at 130 kPa (US Navy procedure). Another group of five experienced male divers (31± 6 years) breathed 60% oxygen (corresponding to the oxygen tension of air at 280 kPa) for 80 min. Before and after exposure, endothelial function was assessed in both groups as flow-mediated dilatation (FMD) by ultrasound in the brachial artery. The results were compared to data obtained froma group of seven healthy individuals of the same age who had never dived. The dive produced few vascular bubbles, buta significant arterialdiameter increase from4.5± 0.7 to4.8± 0.8mm(mean± S.D.) and a significant reduction ofFMDfrom 9.2± 6.9 to 5.0± 6.7% were observed as an indication of reduced endothelial function. In the group breathing oxygen, arterial diameter increased significantly from4.4± 0.3mmto 4.7± 0.3 mm, while FMD showed an insignificant decrease. Oxygen breathing did not decrease nitroglycerine-induced dilatation significantly. In the normal controls the arterial diameter and FMD were 4.1± 0.4mmand 7.7± 0.2.8%, respectively. This study shows that diving can lead to acute arterial endothelial dysfunction inmanand that oxygen breathing will increase arterial diameter after return to breathing air. Further studies are needed to determine if these mechanisms are involved in tissue injury following diving.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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