Naslov
Increased thyroidal T4/T3 in nodular and paranodular tissue of non-toxic goiter following suppressive treatment with thyroid hormones

Autori
Solter, Miljenko ; Tišlarić, Dubravka ; Pegan, Boris ; Petrić, Vlado

Izvornik
Hormone research (0301-0163) 25 (1987); 147-151

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Nontoxic goiter ; suppressive treatment ; thyroidal iodothyronines ; thyroidal T4/T3 ratio

Sažetak
The effect of suppresive treatment with thyroid hormones on thyroidal iodothyronines and T4/T3 ratio in nodular and paranodular tissues was investigated in 12 patients with nontoxic goiter. Results were compared to those from 11 nontreated patients. Continous thyroid hormone administration produced a significant increase in thyroidal T4 and T4/T3 ratio in nodular tissues while T3 remained unchanged. In paranodular tissues a significant rise of T4/T3 ratio, an insignificant increase in T4 and a decrease in T3 were observed following the administration of thyroid hormones. The results are very similar to those obtained in paranodular tissues of autonomously functioning thyroid nodule, and are probably a consequence of suppressed TSH secretion, as TSH predominantly stimulates the synthesis of T3 and/or throidal T4 monodeiodination.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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