Pregled bibliografske jedinice broj: 219360
Botulinum Toxin Type A Reduces Muscle Hyperalgesia in the Rat.
Botulinum Toxin Type A Reduces Muscle Hyperalgesia in the Rat. // The 5th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins, ABSTRACTS (Neurotoxicity Society, USA)Denver, Colorado, Usa 2005
Denver (CO): Neurotoxicity Society, USA, 2005. (poster, nije recenziran, sažetak, znanstveni)
CROSBI ID: 219360 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Botulinum Toxin Type A Reduces Muscle Hyperalgesia in the Rat.
Autori
Lacković, Zdravko
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
The 5th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins, ABSTRACTS (Neurotoxicity Society, USA)Denver, Colorado, Usa 2005
/ - Denver (CO) : Neurotoxicity Society, USA, 2005
Skup
Advancing Research and Improving care. The 5th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins (Neurotoxicity Society, USA)
Mjesto i datum
Denver (CO), Sjedinjene Američke Države, 23.07.2005. - 25.07.2005
Vrsta sudjelovanja
Poster
Vrsta recenzije
Nije recenziran
Ključne riječi
Botulinum toxin; pain
Sažetak
Muscle hyperalgesia in rats was induced with repeated intramuscular acidic saline injections (Sluka KA et al, Muscle Nerve 24:37, 2001). Right gastrocnemius muscle was injected twice with 100 microL l of pH 4 saline four days apart. Rats in one group received botulinum toxin type A (BTX-A ; 5 U/kg) into the plantar surface of the right hind-paws 5 days before the first acidic saline injection, while the second group received BTX-A on the contralateral side. Sensitivity to mechanical stimuli was measured outside the site of injection, on the hind-paws, using the paw-pressure test. Statistics: ANOVA, intergroup differences: Newman-Keuls post hoc test. After the second intramuscular acidic saline injection, significant bilateral hypersensitivity (p<0.01) to mechanical stimuli compared to the control group of rats was observed. Pre-treatment with BTX-A prevented the development of mechanical hyperalgesia on both sides (p<0.001) only when the toxin was injected into the ipsilateral hind-paws. However, when applied contralaterally, the toxin inhibited the development of hypersensitivity on contralateral side only. These results demonstrate the effectiveness of BTX-A in prevention of secondary mechanical hyperalgesia induced by muscle injury. Support: Croatian Ministry of Science, Education and Sport and Deutscher Akademischer Austausch Dienst.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
