Naslov
E-TRACKING EXPLORATION OF CHRONIC SMOKING ON COMMON CAROTID ARTERY

Autori
Kesić, Miljenka-Jelena ; Schon, Frank ; Vuković, Vlasta ; Morović, Sandra ; Budišić, Mislav ; Lovrenčić-Huzjan, Arijana ; Demarin, Vida

Izvornik
Cerebrovascular diseases (1015-9770) 19 (2005), Suppl 1;

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
Chronic smoking; Cerebrovascular ultrasound; Subclinical atherosclerosis
(chronic smoking; cerebrovascular ultrasound; subclinical atherosclerosis)

Sažetak
Background and aim: Chronic effect of smoking on vasculature is of progressive character. Our aim was to assess the difference of carotid stiffness expressed by beta stiffness index and noninvasive one-point measurement of pulse wave velocity between healthy smokers and non-smokers. Patients and methods: There were 41 healthy volunteers investigated with no apparent risk factors for cerebrovascular diseases other than smoking. The patients underwent cardiovascular and risk factor assessment as well as conventional ultrasound examination of the carotid tree. Measurements were performed on Aloka 5500 Prosound ultrasound platform using e-Tracking analysis with ECG trigger. After 15-minute rest in supine position, both common carotid arteries (CCA) were analyzed. T-test assuming unequal variances was performed to determine the difference between the groups. Results: There were 26 women and 15 men, 20 smokers (aged 40, 85+/- 12, 36 yrs) and 21 non-smokers (aged 33, 24+/-7, 87yrs) (p<0, 05). Among the group of smokers average number of pack years was 10, 96+/- 8, 83. Average body-mass index was 25, 61+/-4, 00 kg/m2 in smokers and 23, 41+/-3, 49 kg/m2 (p<0, 05). Average heart rate in smokers was 67, 3+/-4, 1 bpm and in non-smokers 68, 81+/-9, 59 bpm (p>0, 05). Average pulse pressure in smokers was 49+/-10, 36 and in non-smokers 46, 71+/-9, 31 (p<0, 05). There were no side-to-side differences between the indexes in both groups. The groups differed in all stiffness indexes (p<0, 05): beta index on the right CCA of smokers was 8, 46+/-3, 37 and the left 8, 33+/4, 1. In non-smokers beta index in the right CCA 6, 01+/-1, 32 and in the left was 5, 84+/-1, 41. Beta pulse wave velocity in the right CCA of smokers was 6, 04+/-1, 13 m/s and the left 6, 1+/1, 7 m/s. In non-smokers beta pulse wave velocity in the right CCA was 5, 11+/-0, 65 m/s and in the left was 5, 05+/-0, 72 m/s. Discussion: Both beta index and pulse wave velocity describe stiffness. The values of both indexes are within the normal ranges, but are different in respect to each other. This means that the parameters cannot be taken into absolute analysis, rather repeated measurements in the same individual might reveal the change in vascular status. Obtained results indicate that the measured difference is not the consequence of physiological changes and can represent a homogenous sample with a response to chronic smoking. Conclusion: The results of this study indicate that there is difference on subclinical level between smokers and non-smokers when exploring beta stiffness index and single point beta pulse wave velocity. E-tracking is a sensitive method for examination of subclinical atherosclerotic changes of the vessel wall.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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