Naslov
Cerebrospinal fluid of patients with multiple sclerosis

Autori
Poljaković, Zdravka ; Zurak, Niko ; Brinar, Vesna V. ; Koršić, Mirko ; Bašić, Silvio ; Hajnšek, Sanja

Izvornik
Neurologia Croatica. Supplement (1331-5196) 54 (2005), 1;

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
Multiple sclerosis; Growth factors; Growth hormone; Cerebrospinal fluid

Sažetak
Multiple sclerosis (MS) includes a heterogenous group of clinical entities with at least four clinically different forms. While most of our patients have slow progression of the disease, a fast progressive course with fatal prognosis and no signs of remyelinization ability is recorded in 10% of patients. The process of remyelination depends on the healthy condition of axonal media, intact oligodendroglial cells, and interactions of various growth factors, most important of them being insulin growth-factor I (IGF-I). Growth hormone (GH), not only the most important postnatal regulator of IGF-I, a neuroprotective and antiapoptotic agent, also has a direct effect on the process of myelinization, but has never been investigated in cerebrospinal fluid (CSF) of MS patients. In this study, we measured the levels of IGF-I and GH in serum and CSF of 46 MS patients, and compared the findings with the levels of IGF-I and GH in serum and CSF of 49 patients with no signs of demyelinating disease. The results showed a GH deficiency in the CSF of MS patients, and no statistical difference between the two groups in other substances under study. These significantly lower levels of GH and CSF could contribute to the discussion about the ethiopathogenesis of MS and, if proved, may also have a diagnostic, prognostic and therapeutic vaulue.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA