Naslov
Hepatitis C virus population analysis of a single-source nosocomial outbreak reveals an inverse correlation between viral load and quasispecies complexity

Autori
Mas, Antonio ; Ulloa, Encarna ; Bruguera, Miguel ; Furčić, Ivana ; Garriga, Damiá ; Fábregas, Silvia ; Andreu, David ; Sáiz, Juan Carlos ; Díez, Juana

Izvornik
Journal of general virology (0022-1317) 85 (2004), 12; 3619-3626

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
hypervariable region 1 ; sequence variation ; antibody-response ; immune selection ; genetic drift ; infection ; hcv ; evolution ; variants ; disease

Sažetak
The features of Hepatitis C virus (HCV) quasispecies within an envelope segment including the hypervariable region 1 were analysed at an early time point post-infection in seven patients that acquired HCV from a single common donor during a nosocomial outbreak. The grouping of patients according to viral load was reflected in the structure of the quasispecies. A higher viral load correlated with the presence of a predominant HCV genome and a corresponding lower quasispecies complexity. The quasispecies complexity itself was not correlated with HCV clearance or persistence. Thus, the relationship between an intrapatient HCV quasispecies and the clinical outcome of an HCV infection is more complex than previously anticipated.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Kliničke medicinske znanosti

Napomena
This work has been supported by a grant from the Spanish Ministerio de Ciencia y Tecnología (BMC 2001-0834). I.F. was supported in part by the Asociación Española de Cooperación Internacional (AECI).

POVEZANOST RADA