Naslov
Botulinum toxin type-A and pain responsiveness in cervical dystonia: A dose response study

Autori
Relja, Maja ; Telarović, Srđana

Izvornik
Movement disorders (0885-3185) 20 (2005), 10;

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, kongresno priopcenje, znanstveni

Ključne riječi
Botulinum toxin type-1; cervical dystonia

Sažetak
Objective: to compare the efectiveness of different doses of botulinum toxin type-A (BTX-A) for the treatment of motor disability and pain associated with dystonia in patients with painful cervical dystonia. Subjects and Methods: Thirty-eight patients with painful cerival dystonia were enrolled in randomized, double-blind, parallel group, 3-month duration study. At baseline patients received an injection of BTX-A in range from 25 to 150 U. Primary efficacy parameters were the change from the baseline in the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS), pain freuquency and pain severity score. Secondary variables were physician's and patient's global assessment scale. Clinical assessment and side effects ere recorded from the baseline until week 12. Results: Significant pain relief (p<0.01) was obtained in patients treated with 50, 100, and/or 150U of BOTOX already 1 week after injection, while 25 U of BTX-A had no effect. On the contraty, TWSTRS-Total Score was significantly (p<0.01) decreased at 2 weeks post injections, but only in patients who were injected with higher doseses of BTX-a (100 and 150 U of BOTOX). In addition, with two higher BTX-a doses (100 and 150 U of BOTOX) pain reliwef was obtained 1 week post injections, while it took 2 weeks for significant reduction in TWSTRS score. No systemic side effects were noted. Conclusions: These results appear to demonstrate for the first time that BTX-a may have a direct antinociceptive effect distinct from the influence upon the muscle-relaxing properties.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA