Naslov
CNS demyelination and other autoimmune diseases

Autori
Brinar, Vesna V. ; Petelin, Željka ; Djaković, Višnja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 3rd Dubrovnik International Conference on Multiple Sclerosis and Continuing Education ; u: Neurologia Croatica / Brinar, Vesna V. ; Šega Jazbec, Saša ; Poser, Charles M. - Zagreb, 2005, 11-11

Skup
Dubrovnik International Conference on Multiple Sclerosis and Continuing Education (3 ; 2005)

Mjesto i datum
Dubrovnik, Hrvatska, 18.05.2005. - 21.05.2005

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
autoimmune diseases; multiple sclerosis; disseminated encephalomyelitis

Sažetak
Autoimmune diseases in humans represent a diverse group of disorders that generally have unknown cause and poorly understood pathogenesis. They may be organ specific or systemic, giving the various overlap syndromes and occurence of more than one autoimmune disease in the same patient. The different phenotypes are thought to represent a spectrum of immune dysregulation. Many of systemic autoimmune diseases cause central nervous system (CNS) demyelination. The most often demyelinating lesions of CNS in patients with other autoimmune diseases are diagnosed as multiple sclerosis (MS), but in some cases disseminated encephalomyelitis (DEM) is the result of vascular, granulomatous or postinfection manifestations. Numerous case reports have documented that MS can occur concurrently with other autoimmune diseases, mostly with rheumatoid arthritis with the prevalence from 1.8-2.2%, autoimmune thyroid disease with the prevalence from 0.7-1.5%, type I diabetes mellitus with the prevalence from 0.18-0.23 % and pernicious anemia with the prevalence from 0.17-0.23 %. Appearance of DEM in concordance with other autoimmune diseases is rarely described. We have analysed 15 patients with CNS demyelination and other autoimmune diseases, in order to evaluate the type of autoimmune disease and the type of demyelination of the CNS. Some of the patients had disseminated encephalomyelitis and the other had multiple sclerosis. It is important to emphasize that the increased occurrence of autoimmune diseases in patients with MS and in their families, described in the literature, suggests that individuals with MS may have genetic predisposition to autoimmunity in general. Immunological characteristics of individual contribute to the development of different autoimmune diseases, including demyelinating diseases. In accordance with that, some people will develop multiple sclerosis, and the other disseminated encephalomyelitis.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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