Naslov
Učinkovitost moksifloksacina u liječenju respiratornih infekcija: hrvatsko postmarketinško istraživanje
(Efficacy of moxifloxacin in the treatment of respiratory tract infections: the Croatian post-marketing study)

Autori
Kuzman, Ilija, Kincl-Brodnjak, Vladka ; Ermakora, Sonja ; Kovačević, Davor ; Kuzman, Tomislav

Izvornik
Liječnički vjesnik : glasilo Hrvatskoga liječničkog zbora (0024-3477) 127 (2005), 3-4; 77-81

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Kinoloni - terapijska upotreba ; AZA spojevi - terapijska upotreba ; Antibakterijska sredstva - terapijska upotreba ; Infekcije dišnog sustava - farmakoterapija ; Postmarketinški nadzor ; Hrvatska
(Quinolones - therapeutic use ; AZA compounds - therapeutic use ; Anti-bacterial agents - therapeutic use ; Respiratory tract infection - drug therapy ; Product surveillance ; postmarketing ; Croatia)

Sažetak
In this study, we investigated and analysed clinical efficacy and tolerability of moxifloxacin, a new quinolone antibiotic, for the outpatient treatment of bacterial respiratory infections--acute exacerbation of chronic obstructive pulmonary disease (AE- COPD), pneumonia and acute sinusitis. The study was post-marketing and observational, and was conducted after the registration and listing of moxifloxacin in commercial distribution in Croatia. A total of 84 physicians throughout Croatia participated in this study that included 440 patients, 231 with clinically confirmed diagnosis of AE-COPD, 103 with pneumonia and 46 with acute sinusitis. According to physicians, evaluation, 96.8% of the patients were cured. The improvement was recorded on the average after 3.2 days and cure after 6.4 days from the beginning of treatment. Adverse events (48 side effects) were recorded in 40 patients, most commonly suffering from milder gastrointestinal symptoms (nausea, diarrhoea). Serious adverse events were not recorded (phototoxicity, severe hepatic impairment, cardiotoxicity). Moxifloxacin tolerability and patient compliance during treatment were rated as excellent in three- quarters of the patients. Physicians stated they would again prescribe moxifloxacin in 415 or 94.3% of the patients.

Izvorni jezik
Hrvatski

Znanstvena područja
Kliničke medicinske znanosti

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