Naslov
Effect of endosinusal treatment on cellular markers in asthmatics

Autori
Vagić, Davor ; Kalogjera, Livije ; Baudoin, Tomislav ; Geber, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract Book of the 5th European Congress of Oto-Rhino-Laryngology Head and Neck Surgery / - Rodos, 2004, 206-206

Skup
European Congress of Oto-Rhino-Laryngology Head and Neck Surgery (5 ; 2004)

Mjesto i datum
Rodos, Grčka, 11.09.2004. - 16.09.2004

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Nije recenziran

Ključne riječi
Asthma ; chronic rhinosinusitis ; therapy

Sažetak
The aim of the study is to determine the efficacy of topical endosinusal treatment in terms of reduction in activation of inflammatory cells and asthma symptoms in patients with asthma and chronic rhinosinusitis. Eighteen mild-to-moderate asthmatics with chronic rhinosinusitis were subjected to antral sinoscopy and endosinusal treatment with 2 mg of dexamethason and 40 mg of gentamycin per maxillary sinus for 7 days. Sinus lavage and serum samples were taken at the time of inclusion in the study. Forced expiratory volumes in first second (FEV 1) were tested at inclusion and after 30 days. Levels of eosinophil cationic protein (ECP), tryptase and myeloperoxydase were analyzed in serum and sinus fluid before and after treatment. ECP and tryptase levels were significantly reduced in serum and sinus fluid. MPO did not show significant changes after the treatment. FEV 1 significantly improved in whole group. ECP, usually used as a parameter for asthma staging, was mostly affected at the systemic level, while tryptase was more markedly reduced at the local level. The topical endosinusal treatment used in this clinical study significantly reduced activation of eosinophils and mastocytes and improved FEV 1 in mild-to-moderate asthmatics with chronic rhinosinusitis.

Izvorni jezik
Engleski

POVEZANOST RADA