Naslov
Production of Biopharmaceuticals, Antibodies and Edible Vaccines in Transgenic Plants

Autori
Jelaska, Sibila ; Mihaljević, Snježana ; Bauer, Nataša

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Immuno-Modulatory Drugs : Papers presented at the Scientific Conference "Biotechnology and Immuno-Modulatory Drugs" with international participation ; Current Studies of Biotechnology, vol.4 / Kniewald, Zlatko - Zagreb : Medicinska naklada, 2005, 121-127

ISBN
953-176-3151-1

Skup
Scientific Conference "Biotechnology and Immuno-Modulatory Drugs"

Mjesto i datum
Zagreb, Hrvatska, 20.02.2005. - 23.02.2005

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
heterologous proteins; plant-made pharmaceuticals; edible vaccine; molecular farming

Sažetak
The use of plants and other botanicals as a source of medicines exists of the earliest stages of civilization. Despite great advances in synthetic organic chemistry, it is estimated that about one-fourth of present day prescription drugs still have a botanical origin. Recently, and through modern biotechnology, there has been a revival of interest in obtaining new pharmaceuticals from botanical sources. Through genetic modification, it is now recognized that plants are potentially a new source of pharmaceutical proteins including vaccines, antibodies, blood substitutes and other therapeutic entities. Unlike mammalian-derived rRNA drugs, plant-derived antibodies, vaccines and other proteins are particularly advantageous since they are free of mammalian viral vectors and human pathogens. Advantages offered by plants include also low cost of cultivation and high biomass production, relatively fast "gene to protein" time, low capital and operating costs, excellent scalability, eukaryotic posttranslational modification and a relatively high protein yield.

Izvorni jezik
Engleski

Znanstvena područja
Biologija

POVEZANOST RADA